The Women’s Antioxidant and Folic Acid Cardiovascular Study (also known as the Women’s Antioxidant Cardiovascular Study [WACS]) was a randomized, double-blind, placebo-controlled trial evaluating several micronutrients—vitamin E, vitamin C, beta-carotene, and a combined supplement of folic acid, vitamin B6 and vitamin B12—in the prevention of cardiovascular disease events among women at high risk of such events, either because they had a prior history of cardiovascular disease or because they had three or more major risk factors for cardiovascular disease (8,171 women in the vitamin E, vitamin C, and beta-carotene components and 5,442 women in the folic acid/B vitamin component). The trial also examined whether these micronutrients are useful in preventing cancer, vision problems, and cognitive decline.
To read about the main results of WAFACS, please click on the following links:
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- Vitamin E, vitamin C, beta-carotene and cardiovascular disease
- Vitamin E, vitamin C, beta-carotene and cancer
- Vitamin E, vitamin C, beta-carotene and cognitive decline
- Combined folic acid, vitamin B6, and vitamin B12 and cognitive decline
- Combined folic acid, vitamin B6, and vitamin B12 and age-related macular degeneration
- Combined folic acid, vitamin B6, and vitamin B12 and cataract
- Combined folic acid, vitamin B6, and vitamin B12 and cardiovascular disease
- Combined folic acid, vitamin B6, and vitamin B12 and cancer
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