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I-Min Lee, MBBS, ScD

Professor of Medicine, Harvard Medical School
Epidemiologist, Brigham and Women’s Hospital

I-Min Lee’s primary area of interest is in the role of physical activity for preventing chronic diseases and enhancing longevity, and in women’s health. She has published more than 450 scientific articles. She is lead editor of the textbook Epidemiologic Methods in Physical Activity Studies, which has been translated into the Korean language, and is co-editor of Physical Activity Epidemiology, now undergoing its 3rd edition. She has served on national and international expert panels developing physical activity guidelines, including the 2008 US Physical Activity Guidelines, the 2010 WHO Global Recommendations on Physical Activity for Health, and the 2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk. She sits on the international steering committee for the Lancet Physical Activity Series.
She serves as multiple principal investigator of the Women’s Health Study (WHS), a completed clinical trial testing low-dose aspirin and vitamin E for preventing cardiovascular disease and cancer among 40,000 women, 1992-2004, whose participants now continue to be followed observationally. She is principal investigator of a study that objectively measured 7 days of physical activity with accelerometers in 18,000 women from the WHS from 2011-2015; participants are now being followed for various health outcomes and mortality. She is principal investigator of the Harvard Alumni Health Study, a long-standing prospective cohort study of 33,000 Harvard alumni begun by Professor Ralph Paffenbarger in the 1960’s that primarily focuses on the relations of physical activity with long-term health outcomes. She is Co-Investigator in VITAL, a completed clinical trial evaluating the role of vitamin D and omega-3 fatty acid supplements in the primary prevention of cancer and cardiovascular disease among almost 26,000 multiethnic participants throughout the US, 2011-2018, who are currently being followed observationally.

MBBS: National University of Singapore
MPH: Harvard School of Public Health
ScD: Harvard School of Public Health

  1. Lee I-M, Shiroma EJ, Lobelo F, Puska P, Blair SN, Katzmarzyk PT.  Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy.  Lancet 2012;380:219-29.
  2. Ekelund U, Steene-Johannessen J, Brown WJ, Fagerland MW, Owen N, Powell KE, Bauman A, Lee I-MDoes physical activity attenuate or even eliminate the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than one million men and women.  Lancet 2016;388:1302-10.
  3. Manson JE, Cook NR, Lee I-M, Christen W, Bassuk SS, Mora S, Gibson H, Gordon D, Copeland T, D’Agostino D, Friedenberg G, Ridge C, Bubes V, Giovannucci EL, Willett WW, Buring JE for the VITAL Investigators.  Vitamin D supplements and prevention of cancer and cardiovascular disease.  N Engl J Med 2019;380:33-44.
  4. Ekelund U, Tarp J, Steene-Johannessen J, Hansen BH, Jefferis B, Whincup P, Diaz K, Hooker S, Chernofsky A, Larson MG, Murabito J, Spartano N, Dohrn I-M, Hagströmer M, Edvarssson C, Yates T, Shiroma E, Anderssen SA, Lee I-MDose-response associations between accelerometry measured physical activity and sedentary time with all-cause mortality: a harmonised meta-analysis.  BMJ 2019;366:l4570.
  5. Lee I-M, Shiroma EJ, Kamada M, Bassett DR, Matthews CE, Buring JE.  Association of step volume and intensity with all-cause mortality in older women.  JAMA Int Med 2019;179:1105-12.

Full Listing of Publications

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