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Olga V. Demler, PhD

Assistant Professor of Medicine, Harvard Medical School
Associate Biostatistician, Brigham and Women’s Hospital

Dr. Demler is a biostatistician who oversees the design and statistical analysis of a number of metabolomic studies and interventional clinical trials.  Dr. Demler received her Ph.D. degree from Boston University where she worked with Drs D’Agostino and Pencina on the statistical assessment of risk prediction models. She continues this work at the Division, and developed a goodness fit tests in survival setting and for reclassification-calibration statistic with Drs Cook and Paynter. Her methodological research interests include development of rigorous analytic workflows for analyzing metabolomics data and Electronic Medical Records. Dr. Demler’s clinical research interests include cardiovascular disease prevention, lipids, biomarker research, and women’s health. Dr. Demler provides statistical leadership in the analysis of randomized clinical trials and observational studies including Framingham Heart Study, Women’s Health Study, JUPITER trial, the VITaminD and OmegA-3 TriaL (VITAL). Dr. Demler was awarded a five-year career development award (K01) from the National Heart, Lung, and Blood Institute to investigate coronary heart disease risk and metabolic profiles of individuals with discordant lipids.  Dr. Demler is also leading a project funded by the American Heart Association on building a flexible predictive network using large-scale database of Electronic Medical Records from several major Boston-area hospitals.

MS: Stanford University
MA: University of California at Santa Barbara
PhD: Boston University

  1. Demler OV, Paynter NP, Cook NR. Tests of calibration and goodness-of-fit in the survival setting. Stat Med. 2015 May 10;34(10):1659-80. doi: 10.1002/sim.6428. Epub 2015 Feb 11.  PMCID: PMC4555993.
  2. Khera AV, Demler OV, Adelman SJ, Collins HL, Glynn RJ, Ridker PM, Rader DJ, Mora S. Cholesterol Efflux Capacity, High-Density Lipoprotein Particle Number, and Incident Cardiovascular Events: An Analysis From the JUPITER Trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin). Circulation. 2017 Jun 20;135(25):2494-2504. doi: 10.1161/CIRCULATIONAHA.116.025678. Epub 2017 Apr 27. PMCID: PMC5490983.
  3. Antonelli J, Claggett BL, Henglin M, Kim A, Ovsak G, Kim N, Deng K, Rao K, Tyagi O, Watrous JD, Lagerborg KA, Hushcha PV, Demler OV, Mora S, Niiranen TJ, Pereira AC, Jain M, Cheng S. Statistical Workflow for Feature Selection in Human Metabolomics Data. Metabolites. 2019 Jul 12;9(7). doi: 10.3390/metabo9070143.  PMCID: PMC6680705.
  4. Demler OV, Pencina MJ, D’Agostino RB Sr. Impact of correlation on predictive ability of biomarkers. Stat Med. 2013 Oct 30;32(24):4196-210. doi: 10.1002/sim.5824. Epub 2013 May 3. PMCID: PMC4177016.
  5. Demler OV, Pencina MJ, D’Agostino RB Sr. Misuse of DeLong test to compare AUCs for nested models. Stat Med. 2012 Oct 15;31(23):2577-87. doi: 10.1002/sim.5328. Epub 2012 Mar 13. PMCID: PMC3684152.

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