Daniel I. Chasman, PhD
Associate Professor of Medicine
Associate Geneticist
Brigham and Women’s Hospital
dchasman@bwh.harvard.edu
Dr. Chasman is an NIH-funded researcher interested in genome-wide genetic analysis of cardiometabolic traits and other related phenotypes. In particular, his research emphasizes genetic analysis of plasma lipid components, inflammatory biomarkers, pharmacogenetic response to statin therapy, incident vascular disease, and dietary preferences as related to cardiometabolic disease. In addition, he pursues a complementary interest in the genetics of migraine, a neurovascular condition. He is co-PI for the Women’s Genome Health Study (Buring, Lee, Ridker other PIs), a population of over 25,000 women with whole genome genotyping and over 25 years of follow-up for cardiovascular disease. He is also co-PI for genome-wide genetic analysis for JUPITER (Ridker, PI), a trial of rosuvastatin for primary prevention of cardiovascular disease.
AB: Harvard University
PhD: Stanford University
- Chasman, D.I., Shiffman, D., Zee, R.Y., Louie, J.Z., Luke, M.M., Rowland, C.M., Catanese, J.J., Buring, J.E., Devlin, J.J., & Ridker, P.M. (2009). Polymorphism in the apolipoprotein(a) gene, plasma lipoprotein(a), cardiovascular disease, and low-dose aspirin therapy. Atherosclerosis 203(2): 371-376. PMCID: PMC2678922.
- Chasman, D.I., Paré, G., Mora, S., Hopewell, J.C., Peloso, G., Clarke, R., Cupples, L.A., Hamsten, A., Kathiresan, S., Malarstig, A., Ordovas, J.M., Ripatti, S., Parker, A.N., Miletich, J.P., & Ridker, P.M. (2009). Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. PLoS Genet 5(11): e1000730. PMCID: PMC2777390.
- Chasman, D.I., Schürks*, M., Verneri Anttila, Boukje de Vries, Schminke, U., Launer, L.J., Terwindt, G.M., Maagdenberg, A.v.d., Fendrich, K., Völzke, H., Ernst, F., Griffiths, L.R., Buring, J.E., Kallela, M., Freilinger, T., Kubisch, C., Ridker, P.M., Palotie, A., Ferrari, M.D., Hoffmann, W., Zee, R.Y.L., & Kurth, T. (2011). Genome-wide association study reveals three susceptibility loci for common migraine in the general population. Nat Genet 43(7): 695-698. PMCID: PMC3125402.
- Chasman, D.I., Giulianini, F., Macfadyen, J., Barratt, B.J., Nyberg, F., & Ridker, P.M. (2012). Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: The Justification for the Use of Statins in Prevention: An intervention Trial Evaluating Rosuvastatin (JUPITER) trial. Circ Cardiovasc Genet 5(2): 257-264. PMCID: PMCID not needed.
- Chasman, D.I., Anttila, V., Buring, J.E., Ridker, P.M., Schurks, & M., Kurth, T. for the International Headache Genetics Consortium. (2014). Selectivity in genetic association with sub-classified migraine in women. PLoS Genet 10(5): e1004366. PMCID: PMC4031047.