The aim of the Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS) is to evaluate whether reducing inflammation with canakinumab—a human monoclonal antibody that selectively neutralizes the inflammatory marker interleukin-1β (IL-1β)—can reduce rates of future heart attacks and strokes and new onset diabetes among stable coronary artery disease patients with persistently elevated high-sensitivity C-reactive protein levels. This randomized, double-blind, placebo-controlled, multi-center trial is following 10,000 participants in multiple countries.