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Nancy R. Cook, ScD

Professor of Medicine, Harvard Medical School
Senior Biostatistician, Brigham and Women’s Hospital

Dr. Cook is a biostatistician involved in the design, conduct, and analysis of several large randomized trials, including the Women’s Health Study, the Physicians’ Health Study, and the VITamin D and OmegA-3 TriaL (VITAL). She leads the Trials of Hypertension Prevention (TOHP) Follow-up Study, an observational study focusing on the long-term effects of weight loss and sodium reduction interventions on subsequent cardiovascular disease and mortality. Dr. Cook’s methodologic efforts focus on modeling observational data for developing risk prediction scores using clinical and genetic biomarkers. She has helped develop the Reynolds Risk Score for cardiovascular disease as well as improved methodology for comparing and evaluating risk prediction models.

MS: Harvard School of Public Health
ScD: Harvard School of Public Health

  1. Cook NR, Use and misuse of the ROC curve in risk prediction. Circ 2007; 115:928-35. PMID: 17309939
  2. Cook NR, Cutler JA, Obarzanek E, Buring JE, Rexrode KM, Kumanyika SK, Appel LJ, Whelton PK, for the Trials of Hypertension Prevention Collaborative Research Group. The long-term effects of dietary sodium reduction on cardiovascular disease outcomes: Observational follow-up of the Trials of Hypertension Prevention. BMJ 2007; 334:885-8. PMCID: PMC1857760
  3. Cook NR, Lee IM, Zhang SM, Moorthy MV, Buring JE. Alternate-day low-dose aspirin and cancer risk: Long-term observational follow-up of a randomized trial. Ann Intern Med 2013; 159:77-85. PMID: 23856681
  4. Cook NR, Ridker PM. Calibration of the Pooled Cohort Equations for atherosclerotic cardiovascular disease: an update. Ann Intern Med 2016; 165(11):786-794. PMID: 27723890
  5. Cook NR, Appel LA, Whelton PK. Sodium intake and all-cause mortality over 20 years in the Trials of Hypertension Prevention. JACC 2016; 68(15):1609-1617. PMCID: PMC5098805

Full Listing of Publications

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