Pamela M. Rist, ScD
Assistant Professor of Medicine, Harvard Medical School
Associate Epidemiologist, Brigham and Women’s Hospital
prist@mail.harvard.edu
My research interests are focused on the epidemiology of cardiovascular disease (particularly stroke) and neurologic disease (especially those with a vascular component) with the goal of identifying ways to reduce the morbidity burden associated with stroke, migraine, and cognitive decline. In an effort to reduce the morbidity burden from cardiovascular and neurologic disease and understand the underlying biology behind cardiovascular and neurologic disease morbidity, my research has focused on four main areas: (1) the functional consequences of migraine, (2) elucidating factors that ameliorate the impact of cognitive impairment on incident disability, (2) risk factors for functional outcomes from stroke, and (4) risk factors for overall cerebrovascular disease burden in the brains of ischemic stroke patients. In addition to my research activities, I am actively involved in teaching activities at the Harvard T.H. Chan School of Public Health and Harvard Medical School.
MSc: Harvard School of Public Health
ScD: Harvard School of Public Health
Full Listing of Publications
- Shared Genetics of Migraine and Gastrointestinal Disorders Implicates Underlying Neurologic Mechanisms Yet Heterogeneous Etiologies December 16, 2024BACKGROUND AND OBJECTIVES: Migraine is strongly comorbid with irritable bowel syndrome (IBS), one of several gastrointestinal (GI) conditions that are distinguished by symptomatic profiles that are partly overlapping. Potential shared mechanisms of migraine and the GI conditions were investigated by assessing shared genetics on a genome-wide basis.Daniel I Chasman
- Genetically proxied liability to migraine and risk of intracranial aneurysm and subarachnoid hemorrhage November 8, 2024CONCLUSION: Genetic liability to migraine was associated with increased risk of intracranial and extracranial aneurysms, supporting a causal relationship between liability to migraine and these traits. Further work is needed to identify the biological mechanisms and clinical relevance of these findings.Iyas Daghlas
- Migraine and Risk of Parkinson Disease in Women: A Cohort Study August 21, 2024BACKGROUND AND OBJECTIVES: Migraine and Parkinson disease (PD) are common neurologic disorders, which are hypothesized to share some pathophysiologic mechanisms. However, data on the association between migraine and risk of developing PD are sparse. We estimate the effect of migraine, migraine subtypes, and migraine episode frequency on the risk of developing PD in middle-aged and […]Ricarda S Schulz
- Oxylipin Dynamics Following A Single Bout of Yoga Exercise: A Pilot Randomized Controlled Trial Secondary Analysis July 15, 2024Background: Yoga may promote health via a complex modulation of inflammation. Little is known about oxylipins, a class of circulating mediators involved in inflammation resolution. Objective: To explore the acute effects of yoga exercise on systemic levels of oxylipins. Methods: This is a secondary analysis of a three-arm (high-intensity-yoga: HY, n = 10); moderate-intensity-yoga: MY, […]Dennis Muñoz-Vergara
- Omega-3 Fatty Acids and Risk of Ischemic Stroke in REGARDS April 27, 2024We examined associations between lipidomic profiles and incident ischemic stroke in the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. Plasma lipids (n = 195) were measured from baseline blood samples, and lipids were consolidated into underlying factors using exploratory factor analysis. Cox proportional hazards models were used to test associations between lipid […]Zsuzsanna Ament