Clinical studies have provided contradictory findings about the cognitive and mood effects of menopausal hormone therapies and underscored the need for additional research and longer-term effects.
The Kronos Early Estrogen Prevention Study (KEEPS) Continuation study assesses the effects of menopausal hormone therapy and normal aging on cognitive performance and imaging markers of Alzheimer’s disease and brain structure in women who participated in the original KEEPS trial, 13 years after they enrolled in the initial KEEPS trial.