Daniel I. Chasman, PhD
Associate Professor of Medicine
Associate Geneticist
Brigham and Women’s Hospital
dchasman@bwh.harvard.edu
Dr. Chasman is an NIH-funded researcher interested in genome-wide genetic analysis of cardiometabolic traits and other related phenotypes. In particular, his research emphasizes genetic analysis of plasma lipid components, inflammatory biomarkers, pharmacogenetic response to statin therapy, incident vascular disease, and dietary preferences as related to cardiometabolic disease. In addition, he pursues a complementary interest in the genetics of migraine, a neurovascular condition. He is co-PI for the Women’s Genome Health Study (Buring, Lee, Ridker other PIs), a population of over 25,000 women with whole genome genotyping and over 25 years of follow-up for cardiovascular disease. He is also co-PI for genome-wide genetic analysis for JUPITER (Ridker, PI), a trial of rosuvastatin for primary prevention of cardiovascular disease.
AB: Harvard University
PhD: Stanford University
Full Listing of Publications
- Shared Genetics of Migraine and Gastrointestinal Disorders Implicates Underlying Neurologic Mechanisms Yet Heterogeneous Etiologies December 16, 2024BACKGROUND AND OBJECTIVES: Migraine is strongly comorbid with irritable bowel syndrome (IBS), one of several gastrointestinal (GI) conditions that are distinguished by symptomatic profiles that are partly overlapping. Potential shared mechanisms of migraine and the GI conditions were investigated by assessing shared genetics on a genome-wide basis.Daniel I Chasman
- Genetically proxied liability to migraine and risk of intracranial aneurysm and subarachnoid hemorrhage November 8, 2024CONCLUSION: Genetic liability to migraine was associated with increased risk of intracranial and extracranial aneurysms, supporting a causal relationship between liability to migraine and these traits. Further work is needed to identify the biological mechanisms and clinical relevance of these findings.Iyas Daghlas
- Decomposed interaction testing improves detection of genetic modifiers of the relationship of dietary omega-3 fatty acid intake and its plasma biomarkers with hsCRP in the UK Biobank September 24, 2024Discovery and translation of gene-environment interactions (GxEs) influencing clinical outcomes is limited by low statistical power and poor mechanistic understanding. Molecular omics data may help address these limitations, but their incorporation into GxE testing requires principled analytic approaches. We focused on genetic modification of the established mechanistic link between dietary long-chain omega-3 fatty acid (dN3FA) […]Kenneth E Westerman
- Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization September 16, 2024CONCLUSIONS: Our results provided novel glycemic trait associations and highlighted pathways implicated in glycemic regulation. Exome-array summary statistic results are being made available to the scientific community to enable further discoveries.Sara M Willems
- Whole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles September 3, 2024Genetic studies have identified numerous regions associated with plasma fibrinogen levels in Europeans, yet missing heritability and limited inclusion of non-Europeans necessitates further studies with improved power and sensitivity. Compared with array-based genotyping, whole-genome sequencing (WGS) data provide better coverage of the genome and better representation of non-European variants. To better understand the genetic landscape […]Jennifer E Huffman