Dr. Demler is a biostatistician who oversees the design and statistical analysis of a number of metabolomic studies and interventional clinical trials.  Dr. Demler received her Ph.D. degree from Boston University where she worked with Drs D’Agostino and Pencina on the statistical assessment of risk prediction models. She continues this work at the Division, and developed a goodness fit tests in survival setting and for reclassification-calibration statistic with Drs Cook and Paynter. Her methodological research interests include development of rigorous analytic workflows for analyzing metabolomics data and Electronic Medical Records. Dr. Demler’s clinical research interests include cardiovascular disease prevention, lipids, biomarker research, and women’s health. Dr. Demler provides statistical leadership in the analysis of randomized clinical trials and observational studies including Framingham Heart Study, Women’s Health Study, JUPITER trial, the VITaminD and OmegA-3 TriaL (VITAL). Dr. Demler was awarded a five-year career development award (K01) from the National Heart, Lung, and Blood Institute to investigate coronary heart disease risk and metabolic profiles of individuals with discordant lipids.  Dr. Demler is also leading a project funded by the American Heart Association on building a flexible predictive network using large-scale database of Electronic Medical Records from several major Boston-area hospitals.